Adrenal Glands – Cortisone Therapy

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I’ll detail a little about adrenal glands and later on describe the connection between thyroid and adrenal glands.

First, what are adrenal glands and their function in the body.

Adrenal and Thyroid Glands
Adrenal and Thyroid Glands

The adrenals sit just above the kidneys in the loin, one on each side. Their tasks are many and varied; and are so important, that if you lose your adrenals, you die within three days. The inside of each adrenal produces adrenalin, which is the hormone that gives us a sudden burst of energy or strength when confronted with a crisis situation – the “fight or flight” scenario. It is the rim, or cortex, of each adrenal, that most concerns us for the present. It produces a number of complex hormones with vital roles to play, and are essential in the system’s response to prolonged stress; e.g. infection, injury, starvation, massive exertion. The first group is the glucocorticoids (mostly hydrocortisone), whose job is mostly to stimulate conversion of protein to glucose; and maintain the tone of the vascular (or blood vessels) system.

The second group comprises the mineral corticoids, which regulate the proper balance in the body of sodium and potassium, and are therefore to do with fluid retention and blood pressure. Aldosterone is the chief. The third type are the androgens, (male sex hormones), and are represented by Dehydroepiandrosterone, (DHEA for short), and androstendione. These have as their main job, the promotion of repair and growth in the tissues.

Fourthly, are the oestrogen’s, that back up the oestrogen made by the ovaries – as, for example, in the menopause. Other hormones are suspected, but not yet isolated. The output of these hormones is cyclical, with maximum level early in the morning, and least at night.

Our deepest concern here, is the crucial importance of the adrenal cortex hormones in the system’s response to stress. Briefly, there is a rapid increase of the glucocorticoids, to enable the body to cope. It is the failure of this mechanism to work properly, in the presence of general stress, or the stress of illness, that we are concerned with in the use of replacement cortisone therapy.

Additional Blood Tests for Thyroid apart from TSH

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A lot of people and even GPs (Doctors) rely on single test of TSH to identify hypothyroidism or low thyroid function which is totally incorrect.

One of the must have tests is to check FT4 and FT3 at the same time as well which will give a true picture if a person is hypo or hyper. Apart from FT3 and FT4, following tests should also be ordered to complete the picture.

 

ADDITIONAL HEALTH TESTS AND SCREENINGS

Name of test What is this test for? Who should have this test?
Mammogram Low-dose x-ray scan to screen for and detect breast cancer/disease; also available as full-field digital mammography (FFDM) which converts x-rays into electrical signals; best used as companion screening tool with other technology and examinations. Traditionally recommended for women aged 40 and above as a screening device for early detection of breast cancer; also used diagnostically following abnormal clinical findings.
TSH (thyroid-stimulating hormone) Blood test which measures TSH, a hormone excreted by the pituitary gland to stimulate the thyroid to produce thyroid hormone T4 (thyroxine), which is then converted to T3 (triiodothyronine) to be used by the cells; used to evaluate thyroid function and screen for thyroid disorders; sometimes used to diagnose fertility problems. Recommended for symptoms of hypothyroidism (high TSH accompanied by low T4 levels) or hyperthyroidism (low TSH accompanied by high T4 levels), or when thyroid gland is enlarged; routinely used as newborn health screening.
Total thyroxine (T4) Blood test that measures both bound (attached to thyroxine-binding globulin) and free thyroxine. Recommended for symptoms of hyperthyroidism (low TSH accompanied by high T4 levels), or when thyroid gland is enlarged; also used to track treatment effectiveness.
Triiodothyronine (T3) Blood test that measures both bound (attached to thyroxine-binding globulin) and free triiodothyronine. Recommended for symptoms of hypothyroidism (high TSH accompanied by low T4 levels) or hyperthyroidism (low TSH accompanied by high T4 levels), or when thyroid gland is enlarged.
CRP (C-reactive protein) and hs-CRP (high sensitivity C-reactive protein Blood tests used to test for CRP, a marker of inflammation seen in a range of disorders such as inflammatory bowel disease, some types of arthritis, autoimmune function/disease, and pelvic inflammatory disease; to test for low-grade systemic inflammation; also used to screen for potential heart disease and cardiovascular disease; hs-CRP is a newer, more sensitive test that offers earlier detection. For people suspected of having chronic or acute inflammation, risk of heart disease, rheumatoid arthritis or lupus; people who need a screening tool to monitor inflammation or assess treatment effectiveness.
Serum iron, total iron-binding capacity (TIBC) and serum ferritin Blood tests:

  • serum iron test measures the amount of iron in the blood;
  • total iron-binding capacity (TIBC) test measures the amount of transferrin, a protein involved in the transfer of iron from the gut to the cells and bone marrow;
  • serum ferritin test measures the amount of iron reserve stored in the body.
Anyone with symptoms of anemia or who has had an abnormal result in the complete blood count (CBC) may be recommended for all three tests; to evaluate protein depletion or malnutrition; to diagnose a range of more unusual iron-related disorders.
LH (luteinizing hormone) Blood test for LH to evaluate pituitary function. Women with irregular periods; people with fertility issues; people with symptoms of pituitary or hypothalamic disorders; women with symptoms of ovarian disease; girls with delayed or advanced sexual maturation.
FSH (follicle-stimulating hormone) Blood test for FSH to evaluate pituitary function connected to fertility. Women with irregular periods; people with fertility issues; people with symptoms of pituitary or hypothalamic disorders; women with premature ovarian failure; women with symptoms of disease; women with eating disorders; girls with delayed or advanced sexual maturation.
Blood glucose Blood test to determine amount of glucose (blood sugar) in blood; also used as a screening technique; depending on circumstances may be ordered both fasting and possibly 2 hours after a high-sugar meal. Pregnant women; anyone with symptoms of hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar); anyone suspected of having diabetes; anyone with eating disorders; diagnosed diabetics use this test to monitor their condition.
Insulin A set of tests (blood and possibly urine) to help diagnose acute or chronic hypoglycemia; to monitor insulin produced by the body; to check for insulin resistance; to determine if a type-2 diabetic needs to start taking insulin injections; and to diagnose insulinomas (islet cell tumors in the pancreas); depending on circumstances may be ordered both fasting and possibly 2 hours after a high-sugar meal; sometimes a C-peptide test is also required. People concerned about or suspected of having insulin resistance or metabolic syndrome; people with symptoms of hypoglycemia; people diagnosed with type 2 diabetes who may need insulin injections to supplement oral medications; people suspected of having pancreatic disease.
Lipid profile Blood test series which measures total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides; may also include calculated ratio of cholesterol/HDL, or risk scores. Often recommended with routine health exams; also for people with known risk factors for heart disease and/or stroke; people who are already managing cholesterol or heart disease-related issues.
Gastrointestinal (GI) tests This array of tests involve different methods, and can include:

  • colonoscopy or flexible sigmoidoscopy to evaluate health of colon, bowel or large intestine;
  • endoscopic retrograde cholangiopancreatography (ERCP) to evaluate condition of liver, gallbladder, bile ducts, and pancreas;
  • lower GI series to diagnose problems in large intestine;
  • upper endoscopy and upper GI series used to diagnose problems in esophagus, stomach, and duodenum.
People with GI complaints and symptoms, or those suspected of GI disorders or diseases, with the specific recommended tests matched accordingly.
Pap (Papanicolaou) test Sample tissue smear used to screen for cellular changes indicative of potential for cervical cancer and certain vaginal or uterine infections. Girls and women who are sexually active, and those over the age of 18, recommended annually or as directed by practitioner.


Low TSH – “The Unsuspected Illness” – Symptoms

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Because the usual blood tests can be completely normal and the diagnosis can be easily missed.  The correct diagnosis depends on noticing symptoms such as

  • low energy
  • fatigue and tiredness

Other symptoms include:

  • weight gain
  • cold hands and feet
  • depression
  • slowness of thought
  • headaches
  • facial swelling
  • fluid retention
  • dry skin
  • brittle nails
  • constipation
  • irregular menstrual cycles
  • and fertility problems

The body temperature may be low and the patient prefers to set the room thermostat very high and still feels cold.

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